Beilstein J. Org. Chem.2011,7, 1249–1254, doi:10.3762/bjoc.7.145
oxidative coupling with 1,2-dibromoethane. The synthetic ease of this approach compares favourably with previously reported methods and allows for ready access to potentially useful planar chiral derivatives.
Keywords: benzylic metalation; LiNKchemistry; [2.2]metacyclophane; oxidative coupling; planar
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Graphical Abstract
Scheme 1:
Selective benzylic metalation with LiNK conditions. DG = directing group.